GSK adopts antisense

Gsk-3β

Despite continuous advances in the knowledge of breast cancer pathophysiology, this type of neoplasia remains a leading cause of cancer-related death in women, with more than 450 000 deaths every year worldwide. 1 surgery, coupled with radiation and/or che-motherapy, remains the main approach for breast cancer treatment. However, another common therapeutic option is based on the use of the estr...

Novel Reporter Alleles of GSK-3α and GSK-3β

Glycogen Synthase Kinase 3 (GSK-3) is a key player in development, physiology and disease. Because of this, GSK-3 inhibitors are increasingly being explored for a variety of applications. In addition most analyses focus on GSK-3β and overlook the closely related protein GSK-3α. Here, we describe novel GSK-3α and GSK-3β mouse alleles that allow us to visualise expression of their respective mRNA...

The JAAD adopts the CONSORT statement.

ANSI adopts IGES for CAD / CAM systems

data types. The notion of abstract data types is relatively recent. Germans have the feeling that CAD/CAM "Too often the people who introduce and computer graphics technology can computer-aided design and computer improve the qualitv of products, according graphics to an organization disregard the to Jose L. Encarnacao, Eurographics social consequences and the human factors," chairman. They wan...

Presenilin adopts the ClC channel fold

Presenilin is an integral membrane aspartate protease that regulates cellular processes by cleaving proteins within the cell membrane. The recent crystal structure of presenilin reveals a conspicuous pore in a bundle of nine α-helices, which was originally thought to adopt a novel protein fold. However, here I show that the presenilin fold is a variant of the ClC chloride channel/transporter fo...